About darolutamide
Androgen receptor inhibitor
Used for
- Treats prostate cancer that has not spread, with rising PSA despite hormone therapy.
- Treats metastatic hormone-sensitive prostate cancer with hormone therapy, sometimes alongside docetaxel.
Usual adult dose
600 mg by mouth twice daily with food; reduce dose for certain side effects or severe kidney or liver problems.
Common side effects
- Tiredness
- Rash
- Limb pain
- Heart disease or high blood pressure
Important warnings
- Continue medical castration unless the testes have been surgically removed.
- Seizures have occurred; use caution with seizure history or other seizure risks.
- Check for liver problems and interactions before treatment.
- May harm an unborn baby; effective contraception is needed during treatment and for one week afterward.
Pregnancy
Not for use during pregnancy; it may harm an unborn baby.
Breastfeeding
Not indicated; safety during breastfeeding is not established.
Interactions
- Some medicines can increase darolutamide levels; examples include itraconazole.
- Darolutamide can reduce levels of medicines such as midazolam and rosuvastatin.
- Avoid strong enzyme inducers such as rifampin, which can reduce darolutamide levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.