About sofosbuvir
Direct-acting antiviral; NS5B polymerase inhibitor
Used for
- Treats chronic hepatitis C, combined with other antiviral medicines.
Usual adult dose
Usually 400 mg by mouth once daily with other hepatitis C medicines; regimen and duration depend on the infection and treatment history.
Usual dose in children
For children aged 3 years or older, dose is weight-based once daily with other hepatitis C medicines; specialist-directed.
Common side effects
- Headache
- Fatigue
- Nausea
- Insomnia
Important warnings
- Do not use alone to treat hepatitis C.
- Hepatitis B may reactivate during or after treatment; screening is recommended.
- Amiodarone with sofosbuvir-containing treatment can cause dangerously slow heart rate.
- Treatment choice depends on liver disease, prior treatment, and other medicines.
Pregnancy
Sofosbuvir is used with other medicines; pregnancy risks depend on the full regimen. Ribavirin must not be used during pregnancy.
Breastfeeding
Limited information is available; safety depends on the accompanying medicines and clinical circumstances.
Interactions
- Amiodarone: risk of severe bradycardia with sofosbuvir-containing regimens.
- Rifampin and St. John's wort can reduce sofosbuvir levels.
- Some anticonvulsants, including carbamazepine and phenytoin, can reduce antiviral levels.
- Acid-reducing medicines can interact with certain companion antivirals, such as velpatasvir.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.