About sirolimus
mTOR inhibitor immunosuppressant
Used for
- Prevention of kidney transplant rejection, usually with other immunosuppressants
- Treatment of lymphangioleiomyomatosis
- Treatment of certain rare tumors, depending on formulation and local approval
Usual adult dose
Kidney transplant: dosing is individualized using blood levels. Lymphangioleiomyomatosis: 2 mg once daily, adjusted to blood levels.
Usual dose in children
Kidney transplant: specialist-directed, weight- and blood-level-based dosing. Not routinely used for children with lymphangioleiomyomatosis.
Common side effects
- Mouth sores, diarrhea, nausea, or abdominal pain
- Swelling, high blood pressure, or increased cholesterol and triglycerides
- Low blood-cell counts or increased infection risk
- Delayed wound healing, rash, or acne
Important warnings
- Can cause serious infections and increase the risk of some cancers.
- May impair wound healing and cause lung inflammation or kidney problems.
- Regular blood tests are needed; do not stop transplant treatment without medical direction.
- Avoid grapefruit and grapefruit juice; use only the prescribed measuring device.
Pregnancy
May harm an unborn baby. Effective contraception is advised during treatment and for 12 weeks after stopping.
Breastfeeding
Breastfeeding is not recommended during treatment and for 2 weeks after the last dose.
Interactions
- Strong CYP3A4 or P-glycoprotein inhibitors, such as clarithromycin, can raise sirolimus levels.
- Strong CYP3A4 or P-glycoprotein inducers, such as rifampin, can lower sirolimus levels.
- Grapefruit can raise levels; live vaccines may be less safe or effective.
- Other immunosuppressants can increase infection risk; ACE inhibitors may increase angioedema risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.