About roflumilast
Phosphodiesterase-4 inhibitor
Used for
- Long-term treatment to reduce COPD flare-ups in adults with severe chronic bronchitis.
- Not for sudden breathing problems or asthma.
Usual adult dose
500 micrograms by mouth once daily for COPD.
Common side effects
- Diarrhea, nausea, or reduced appetite
- Weight loss
- Headache or dizziness
- Insomnia or mood changes
Important warnings
- May cause significant weight loss; monitor body weight.
- Report new or worsening depression, suicidal thoughts, or unusual behavior.
- Avoid in moderate-to-severe liver impairment.
- Not a rescue medicine for sudden breathing difficulty.
Pregnancy
Safety is not well established; use only when a clinician determines it is needed.
Breastfeeding
It is unknown whether roflumilast passes into breast milk; discuss risks with a clinician.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, may raise roflumilast levels.
- Rifampin and other enzyme-inducing medicines may reduce its effect.
- Theophylline may increase side effects when taken with roflumilast.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.