About dapsone
Sulfone antibiotic and anti-inflammatory
Used for
- Treats dermatitis herpetiformis, alongside a gluten-free diet.
- Treats leprosy as part of combination therapy.
- Prevents Pneumocystis pneumonia in selected people when other options are unsuitable.
Usual adult dose
Dermatitis herpetiformis: usually 50 mg daily initially, adjusted gradually; maximum 300 mg daily. Leprosy: dosing depends on the combination regimen.
Usual dose in children
Leprosy: usually 1–2 mg/kg daily, up to 100 mg, as part of combination therapy.
Common side effects
- Nausea, headache, or rash
- Haemolytic anaemia, especially with G6PD deficiency
- Methaemoglobinaemia
- Rare severe skin reactions or liver problems
Important warnings
- Blood tests are needed before and during treatment.
- Risk of blood-cell problems is higher with G6PD deficiency.
- Seek urgent assessment for breathing difficulty, blue lips, severe rash, or unusual bruising.
- Use caution with anaemia, heart or lung disease, and liver problems.
Pregnancy
May be used when necessary after clinical assessment; discuss risks and benefits with a healthcare professional.
Breastfeeding
Dapsone enters breast milk and may cause haemolysis in infants, especially premature or G6PD-deficient babies.
Interactions
- Rifampicin can lower dapsone levels.
- Trimethoprim may increase dapsone exposure and blood-related adverse effects.
- Other medicines that cause haemolysis or methaemoglobinaemia may increase risks.
- Folic acid antagonists, such as pyrimethamine, may increase blood toxicity.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.