About milnacipran
Serotonin-norepinephrine reuptake inhibitor
Used for
- Treatment of major depressive disorder in some countries
Usual adult dose
For depression, commonly 50 mg twice daily after gradual dose increases; dosing varies by country and kidney function.
Common side effects
- Nausea
- Headache
- Constipation
- Increased sweating
Important warnings
- May increase blood pressure and heart rate.
- Can cause serotonin syndrome, especially with other serotonergic medicines.
- Stopping suddenly may cause withdrawal symptoms; tapering is usually needed.
- May increase suicidal thoughts in young adults, especially early in treatment.
Pregnancy
Use during pregnancy requires individualized assessment; data are limited, and late-pregnancy exposure may affect the newborn.
Breastfeeding
Information is limited; milnacipran may enter breast milk, so infant effects are uncertain.
Interactions
- MAO inhibitors can cause dangerous reactions; avoid combined use.
- Other serotonergic medicines increase serotonin syndrome risk.
- Medicines affecting blood pressure or heart rate may increase cardiovascular effects.
- Milnacipran can increase bleeding risk with anticoagulants or NSAIDs.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.