About ofatumumab
Anti-CD20 monoclonal antibody
Used for
- Treats relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome.
Usual adult dose
20 mg under the skin at weeks 0, 1, and 2, then every month starting week 4.
Common side effects
- Injection-related reactions, such as fever, headache, chills, or nausea
- Upper respiratory infections
- Urinary tract infections
- Headache
Important warnings
- Screen for hepatitis B before treatment; reactivation can occur.
- Check immunoglobulin levels and infection risk during treatment.
- Avoid live vaccines during treatment and until B-cell recovery.
- Treatment may lower vaccine responses and increase infection risk.
Pregnancy
Human pregnancy data are limited. Potential fetal harm is a concern; discuss pregnancy plans with a clinician.
Breastfeeding
It is not known whether ofatumumab passes into breast milk; discuss treatment and infant risks with a clinician.
Interactions
- Live vaccines may cause infection and should be avoided during treatment.
- Other immunosuppressive medicines may increase infection risk or immune suppression.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.