About voriconazole
Triazole antifungal
Used for
- Treats serious fungal infections, including invasive aspergillosis and candidiasis.
- Treats certain serious infections caused by Scedosporium or Fusarium fungi.
Usual adult dose
Usually 400 mg twice on day one, then 200 mg twice daily; doses vary by infection and response.
Usual dose in children
For ages 2 to under 12, or ages 12–14 under 50 kg: usually 9 mg/kg twice on day one, then 8 mg/kg twice daily. Specialist dosing required.
Common side effects
- Visual changes, such as blurred vision or altered color perception
- Nausea, vomiting, diarrhea, or abdominal pain
- Rash, headache, or elevated liver enzymes
- Sun sensitivity and skin reactions
Important warnings
- Can cause serious liver injury; liver tests are monitored during treatment.
- Can cause vision effects; avoid driving if vision is affected.
- Sun exposure may cause severe skin reactions and increase skin cancer risk.
- Many interactions and heart-rhythm risks; treatment requires medical supervision.
Pregnancy
May harm an unborn baby; generally avoided during pregnancy unless clearly necessary.
Breastfeeding
Unknown whether it passes into breast milk; breastfeeding decisions require clinical review.
Interactions
- Rifampin, carbamazepine, and St John’s wort can reduce voriconazole levels.
- Voriconazole can raise levels of warfarin, some statins, and transplant medicines.
- Some HIV medicines and drugs affecting heart rhythm can cause serious interactions.
- Acid-reducing medicines and other antifungals may alter voriconazole levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.