About efavirenz
Non-nucleoside reverse transcriptase inhibitor
Used for
- Used with other HIV medicines to treat HIV-1 infection.
Usual adult dose
Usually 600 mg by mouth once daily with other HIV medicines.
Usual dose in children
For children at least 3 months old and weighing at least 3.5 kg: dose is weight-based, once daily, with other HIV medicines.
Common side effects
- Dizziness, trouble sleeping, unusual dreams
- Rash
- Headache and tiredness
- Nausea
Important warnings
- May cause serious psychiatric symptoms, including depression or suicidal thoughts.
- Rash can be severe; urgent assessment is needed for blistering or peeling.
- Can cause liver injury; risk is higher with hepatitis or liver disease.
- Does not prevent HIV transmission; use with other prescribed HIV medicines.
Pregnancy
Efavirenz may be used during pregnancy when clinically appropriate; treatment decisions should consider current HIV guidance and pregnancy status.
Breastfeeding
Breastfeeding is generally not recommended with HIV because of transmission risk; local guidance may differ.
Interactions
- Many medicines interact; efavirenz can lower levels of some drugs, including hormonal contraceptives.
- Avoid St John’s wort; it can reduce efavirenz levels.
- Some seizure medicines, rifampin, and antifungals may require clinician review or dose changes.
- Check all prescription, nonprescription, and herbal products for interactions.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.