About digoxin immune fab
Digoxin-specific antibody fragment
Used for
- Treatment of life-threatening digoxin toxicity or overdose.
- Treatment of life-threatening toxicity from certain related cardiac glycosides.
Usual adult dose
Dose depends on the amount ingested or serum digoxin concentration; given intravenously in a monitored setting.
Usual dose in children
Dose depends on the amount ingested or serum digoxin concentration; given intravenously in a monitored setting.
Common side effects
- Low blood potassium
- Worsening heart failure or rapid heartbeat
- Allergic reactions, including severe reactions
- Low blood pressure
Important warnings
- Can reduce potassium dangerously; monitor blood potassium and heart rhythm.
- May worsen heart failure or trigger rapid heart rhythms.
- Digoxin blood tests can be misleading after treatment.
- Use caution with allergy to sheep proteins or papain.
Pregnancy
Use for serious toxicity when needed; untreated severe digoxin poisoning can endanger the pregnant patient and fetus.
Breastfeeding
There is limited information; treatment of life-threatening toxicity may be necessary during breastfeeding.
Interactions
- Reverses digoxin effects and may reduce its therapeutic benefit.
- May also bind other cardiac glycosides, including digitoxin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.