About pamidronate disodium
Bisphosphonate bone-resorption inhibitor
Used for
- High blood calcium caused by cancer
- Bone damage from multiple myeloma or metastatic breast cancer
- Paget disease of bone
Usual adult dose
Dose depends on the condition; commonly 60–90 mg by slow intravenous infusion. Paget disease: 30 mg daily for three days.
Common side effects
- Fever or flu-like symptoms
- Nausea
- Low blood calcium or phosphate
- Infusion-site irritation
Important warnings
- Must be given by slow intravenous infusion, not injection into a vein rapidly.
- Kidney function should be checked; kidney injury is possible.
- Low calcium or vitamin D can increase complications.
- Rarely, jawbone damage or unusual thigh fractures occur.
Pregnancy
Use is generally avoided during pregnancy; human safety information is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment; effects on milk are uncertain.
Interactions
- Other medicines that can harm the kidneys may increase kidney-injury risk.
- Calcium-lowering medicines may increase the risk of low blood calcium.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.