About celecoxib
Selective COX-2 nonsteroidal anti-inflammatory drug
Used for
- Osteoarthritis and rheumatoid arthritis
- Ankylosing spondylitis
- Short-term pain, including menstrual pain
- Juvenile rheumatoid arthritis in children aged two years and older
Usual adult dose
Usually 200 mg daily for osteoarthritis; other conditions may require 200 mg twice daily, depending on the indication.
Usual dose in children
For juvenile arthritis, usually 50 mg twice daily for children weighing 10–25 kg, or 100 mg twice daily above 25 kg.
Common side effects
- Indigestion, stomach pain, or diarrhea
- Headache or dizziness
- Swelling of the legs
- Rash
Important warnings
- Can increase risk of heart attack, stroke, and blood clots.
- May cause stomach ulcers or bleeding, sometimes without warning.
- Can worsen high blood pressure, heart failure, or kidney problems.
- Avoid with sulfonamide allergy; serious skin reactions are possible.
Pregnancy
Avoid from 20 weeks unless specifically directed; avoid from 30 weeks because it may harm the fetus.
Breastfeeding
Small amounts pass into milk; short-term use is generally considered compatible, but evidence is limited.
Interactions
- Blood thinners, aspirin, and other NSAIDs increase bleeding risk.
- ACE inhibitors, ARBs, and diuretics may affect kidney function or blood pressure.
- Fluconazole can increase celecoxib levels; rifampin can lower them.
- Lithium levels may rise; monitor when used together.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.