About asfotase alfa
Enzyme replacement therapy
Used for
- Treats perinatal-, infantile-, and juvenile-onset hypophosphatasia
- Helps improve bone mineralization and reduce disease complications
Usual adult dose
Usually 6 mg/kg weekly, divided into three or six subcutaneous injections; specialists may adjust the schedule.
Usual dose in children
Usually 6 mg/kg weekly, divided into three or six subcutaneous injections; specialists may adjust the schedule.
Common side effects
- Injection-site reactions
- Headache
- Nausea
- Lipodystrophy or calcium deposits near injection sites
Important warnings
- Severe allergic reactions can occur.
- Injection-site reactions may include skin changes or tissue damage.
- Ectopic calcifications, including eye or kidney deposits, have been reported.
- The medicine may interfere with some laboratory tests using alkaline phosphatase.
Pregnancy
Human pregnancy data are limited; use during pregnancy requires weighing potential benefits and risks.
Breastfeeding
It is unknown whether asfotase alfa passes into breast milk; discuss potential benefits and risks with a healthcare professional.
Interactions
- No well-established drug interactions are known.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.