About midodrine hydrochloride
Alpha-1 adrenergic receptor agonist
Used for
- Treats symptomatic orthostatic hypotension, a significant blood-pressure drop on standing.
Usual adult dose
Usually 2.5–10 mg three times daily during daytime; avoid doses within four hours of bedtime.
Common side effects
- Scalp tingling or itching
- Goosebumps or chills
- Difficulty passing urine
- Raised blood pressure when lying down
Important warnings
- Can cause dangerously high blood pressure while lying down.
- Avoid taking near bedtime; remain upright after doses where possible.
- Use caution with urinary retention, kidney problems, or heart disease.
- Regular blood-pressure monitoring is important during treatment.
Pregnancy
Use is generally avoided because safety information in pregnancy is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment; safety information is limited.
Interactions
- Medicines that raise blood pressure may increase the risk of hypertension.
- Digoxin or other heart-rate-lowering medicines may cause a slower heartbeat.
- Monoamine oxidase inhibitors and linezolid may increase blood pressure.
- Corticosteroids or decongestants may worsen high blood pressure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.