About cloxacillin
Penicillinase-resistant penicillin antibiotic
Used for
- Treats susceptible staphylococcal skin, soft-tissue, bone, and respiratory infections.
Usual adult dose
Usually 250–500 mg by mouth every 6 hours, depending on infection.
Usual dose in children
Usually 12.5–25 mg/kg by mouth every 6 hours; dose depends on infection.
Common side effects
- Nausea, vomiting, diarrhea, or abdominal discomfort
- Rash or itching
- Rare severe allergic reaction
Important warnings
- Do not use with a serious penicillin allergy.
- Seek urgent care for facial swelling, breathing difficulty, or severe rash.
- Antibiotics do not treat viral infections.
- Complete the prescribed course unless a clinician changes it.
Pregnancy
Generally considered acceptable when clinically needed; human pregnancy data are limited.
Breastfeeding
Usually compatible; small amounts may enter milk and occasionally cause infant diarrhea or thrush.
Interactions
- Probenecid may increase cloxacillin levels.
- Warfarin effects may change; monitoring may be needed.
- Methotrexate toxicity may increase.
- Taking it with food can reduce absorption; it is usually taken on an empty stomach.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.