About sitaxentan
Endothelin receptor antagonist
Used for
- Previously used to treat pulmonary arterial hypertension (PAH).
Usual adult dose
Historically, 100 mg by mouth once daily; withdrawn from use in many countries.
Common side effects
- Liver injury, sometimes severe or fatal
- Headache
- Nausea
- Swelling of the legs or ankles
Important warnings
- Withdrawn or suspended in many countries because of serious liver toxicity.
- Liver failure and deaths were reported; liver monitoring was required.
- Do not use with moderate or severe liver impairment.
- Can cause fetal harm; pregnancy prevention was required.
Pregnancy
May harm an unborn baby; contraindicated during pregnancy.
Breastfeeding
Whether sitaxentan passes into breast milk is unknown; breastfeeding safety is not established.
Interactions
- Warfarin: sitaxentan can increase its effects and bleeding risk; close monitoring was required.
- Cyclosporine can substantially increase sitaxentan levels; combination is contraindicated.
- Other medicines affecting liver enzymes may alter sitaxentan levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.