About amifampridine phosphate
Potassium channel blocker
Used for
- Improves muscle strength in Lambert-Eaton myasthenic syndrome (LEMS).
Usual adult dose
For LEMS, usually starts at 15–30 mg daily in divided doses; adjusted gradually, maximum 80 mg daily.
Usual dose in children
For children aged 6 years and older with LEMS, dosing is based on body weight and divided throughout the day.
Common side effects
- Tingling or numbness around the mouth or in the limbs
- Headache
- Nausea or abdominal pain
- Seizures
Important warnings
- Can cause seizures, even without a prior seizure history.
- Use cautiously with kidney or liver impairment.
- Avoid in people with a history of seizures.
- Abrupt interruption may worsen LEMS symptoms.
Pregnancy
Human pregnancy information is limited; use only when the expected benefit outweighs potential risk.
Breastfeeding
It is unknown whether amifampridine passes into breast milk; effects on infants are uncertain.
Interactions
- Medicines that lower the seizure threshold may increase seizure risk.
- Other cholinergic medicines may increase side effects.
- Drugs that prolong the QT interval may raise heart-rhythm risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.