About clozapine
Atypical antipsychotic
Used for
- Treatment-resistant schizophrenia
- Reducing recurrent suicidal behavior in schizophrenia or schizoaffective disorder
Usual adult dose
Usually starts at 12.5 mg once or twice daily, then increases gradually; commonly 300–450 mg daily, divided.
Common side effects
- Sleepiness, dizziness, and increased saliva
- Constipation
- Weight gain and increased blood sugar
- Fast heartbeat
Important warnings
- Can dangerously lower white blood cells; regular blood tests are required.
- Severe constipation can cause life-threatening bowel complications.
- May cause seizures, fainting, or heart inflammation, especially during dose increases.
- Stopping or restarting after an interruption requires careful dose management.
Pregnancy
Use only when the expected benefit outweighs potential risks; do not stop suddenly without medical guidance.
Breastfeeding
Clozapine may cause serious effects in a nursing infant; breastfeeding is generally not recommended.
Interactions
- Smoking changes can alter clozapine levels.
- Fluvoxamine and ciprofloxacin can raise clozapine levels.
- Other medicines that suppress bone marrow increase blood risks.
- Sedatives and alcohol can worsen sleepiness and dizziness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.