About hydroxurea
Antimetabolite; antineoplastic agent
Used for
- Treats certain blood cancers, including chronic myeloid leukemia.
- Helps reduce painful crises in sickle cell disease.
- Treats some head and neck cancers alongside radiation.
Usual adult dose
Varies by condition and blood counts; commonly 15–30 mg/kg once daily for sickle cell disease. Cancer dosing is individualized.
Usual dose in children
For sickle cell disease, commonly 15 mg/kg once daily, adjusted by blood counts. Specialist supervision is required.
Common side effects
- Low blood cell counts and increased infection or bleeding risk
- Nausea, vomiting, diarrhea, or constipation
- Mouth sores and reduced appetite
- Skin or nail changes
Important warnings
- Can cause severe bone marrow suppression; regular blood tests are essential.
- May cause fetal harm; effective contraception is required during treatment and afterward.
- Long-term use may increase risk of skin cancer and other cancers.
- Do not open capsules; avoid contact with capsule contents.
Pregnancy
May harm an unborn baby. Avoid use during pregnancy unless a specialist determines it is essential.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one week after the last dose.
Interactions
- Didanosine or stavudine may increase risk of pancreatitis, liver injury, or nerve damage.
- Other medicines that suppress bone marrow can worsen low blood counts.
- Live vaccines may pose increased infection risk during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.