About Serzone 100mg Tablets
Serotonin antagonist and reuptake inhibitor antidepressant
Used for
- Major depressive disorder
Usual adult dose
Usually 100 mg twice daily initially; adjusted gradually, commonly 300–600 mg daily in divided doses.
Common side effects
- Drowsiness or dizziness
- Nausea
- Dry mouth
- Blurred vision
Important warnings
- Rare severe liver injury, including liver failure, has occurred.
- Stop treatment and seek urgent medical assessment for signs of liver problems.
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause serotonin syndrome or worsen mania in susceptible people.
Pregnancy
Use during pregnancy requires weighing potential benefits against risks; discuss with a clinician.
Breastfeeding
Nefazodone may enter breast milk; infant effects are uncertain, so use requires clinical assessment.
Interactions
- Do not combine with MAO inhibitors; allow required washout periods.
- Strong CYP3A4 inhibitors can raise nefazodone levels; combination is contraindicated.
- Nefazodone can dangerously increase levels of some medicines, including certain statins and sedatives.
- Alcohol and other sedating medicines can worsen drowsiness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.