About perampanel
Antiseizure medication; AMPA receptor antagonist
Used for
- Treats partial-onset seizures, with or without spread to both sides of the brain.
- Treats primary generalized tonic-clonic seizures.
Usual adult dose
Usually starts at 2 mg once daily at bedtime; increased gradually. Typical maintenance is 4–12 mg once daily, depending on seizure type and other medicines.
Usual dose in children
For children aged 4 years and older: starts at 2 mg once daily at bedtime; increased gradually. Maintenance varies by age, weight, seizure type, and other medicines.
Common side effects
- Dizziness, sleepiness, or fatigue
- Falls or poor coordination
- Irritability or other mood changes
- Nausea or weight gain
Important warnings
- Can cause serious aggression, hostility, or other behavioral changes.
- May cause dizziness, sleepiness, falls, or impaired coordination.
- Do not stop suddenly; seizures may worsen.
- Misuse can lead to dependence; risk is higher with a history of substance misuse.
Pregnancy
May harm an unborn baby; pregnancy-registry data are limited. Discuss risks with a healthcare professional.
Breastfeeding
It is unknown whether perampanel passes into breast milk; effects on a nursing infant are uncertain.
Interactions
- Hormonal contraceptives containing levonorgestrel may work less well.
- Carbamazepine, oxcarbazepine, and phenytoin can lower perampanel levels.
- Alcohol and other medicines that cause sleepiness may worsen sedation or coordination problems.
- Perampanel can increase levels of some medicines, including midazolam.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.