About quetiapine fumarate
Atypical antipsychotic
Used for
- Schizophrenia
- Bipolar disorder, including manic and depressive episodes
- Add-on treatment for major depressive disorder in some countries
Usual adult dose
Usually started at 25–50 mg once or twice daily, then increased gradually. Typical total doses are 150–800 mg daily, depending on the condition and formulation.
Usual dose in children
Specialist-prescribed for schizophrenia or bipolar mania from age 10; dosing starts low and is adjusted by age, condition, and response.
Common side effects
- Sleepiness, dizziness, and dry mouth
- Constipation and fast heartbeat
- Weight gain and increased blood sugar or cholesterol
- Drop in blood pressure when standing
Important warnings
- Can cause severe sleepiness and impair driving or coordination.
- May increase blood sugar, blood fats, and weight.
- Older adults with dementia-related psychosis have increased risk of death; not approved for this use.
- Do not stop suddenly without medical guidance; withdrawal symptoms can occur.
Pregnancy
Use only when clinically needed; discuss risks and benefits. Late-pregnancy use may cause newborn movement, feeding, or breathing problems.
Breastfeeding
Quetiapine passes into breast milk in small amounts. Monitor the infant for unusual sleepiness or feeding difficulties.
Interactions
- Alcohol and sedating medicines can worsen sleepiness.
- Strong CYP3A4 inhibitors, such as clarithromycin, can raise quetiapine levels.
- Carbamazepine, phenytoin, and rifampicin can lower quetiapine levels.
- Medicines affecting heart rhythm may increase abnormal-rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.