About nintedanib esilate
Tyrosine kinase inhibitor
Used for
- Slows lung-function decline in idiopathic pulmonary fibrosis.
- Treats chronic fibrosing interstitial lung diseases with a progressive phenotype.
- Slows lung-function decline in systemic sclerosis-associated interstitial lung disease.
Usual adult dose
Usually 150 mg by mouth twice daily with food; 100 mg twice daily may be used for side effects or liver problems.
Common side effects
- Diarrhea
- Nausea or vomiting
- Abdominal pain
- Liver enzyme increases
Important warnings
- Can cause serious liver injury; liver tests are needed before and during treatment.
- May increase bleeding risk and cause gastrointestinal perforation.
- Can cause harm to an unborn baby; pregnancy testing and effective contraception are recommended.
- Use caution with heart disease, bleeding disorders, and recent abdominal surgery.
Pregnancy
May cause fetal harm. Avoid during pregnancy; effective contraception is recommended during treatment and for at least three months after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least three days after the last dose.
Interactions
- Strong P-glycoprotein/CYP3A4 inhibitors may increase nintedanib exposure.
- P-glycoprotein/CYP3A4 inducers may reduce its effectiveness.
- Anticoagulants or other medicines that increase bleeding may raise bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.