About efavirenz
Non-nucleoside reverse transcriptase inhibitor
Used for
- Treats HIV-1 infection, combined with other HIV medicines.
Usual adult dose
600 mg once daily by mouth, with other HIV medicines.
Usual dose in children
For children at least 3 months old and weighing at least 3.5 kg: dose is weight-based, once daily; specialist guidance is required.
Common side effects
- Dizziness, trouble sleeping, vivid dreams, or difficulty concentrating
- Rash
- Nausea, headache, or tiredness
- Mood changes or depression
Important warnings
- Can cause serious rash or severe allergic reactions.
- May worsen depression or cause suicidal thoughts, confusion, or unusual behavior.
- Can harm the liver; monitoring may be needed.
- Does not cure HIV or prevent transmission.
Pregnancy
Can be used during pregnancy when clinically appropriate; treatment should be reviewed with an HIV specialist. Avoid becoming pregnant during treatment and for 12 weeks afterward.
Breastfeeding
HIV can pass to the baby through breast milk; breastfeeding is generally not recommended where safe alternatives are available.
Interactions
- Many medicines interact; efavirenz can reduce hormonal contraceptive effectiveness.
- Do not take with voriconazole or certain other medicines, including some heart-rhythm drugs.
- St John’s wort can lower efavirenz levels and should be avoided.
- Antacids or food do not replace careful review of all medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.