About paromomycin sulphate
Aminoglycoside antibiotic
Used for
- Treats intestinal amoebiasis caused by Entamoeba histolytica.
- Treats certain intestinal tapeworm infections.
- Sometimes used to reduce gut bacteria before surgery or manage hepatic encephalopathy.
Usual adult dose
Amoebiasis: 25–35 mg/kg/day by mouth in three divided doses for 5–10 days; other uses differ.
Usual dose in children
Amoebiasis: 25–35 mg/kg/day by mouth in three divided doses for 5–10 days; specialist guidance is needed.
Common side effects
- Diarrhoea
- Nausea or vomiting
- Abdominal cramps
- Rarely, allergic reactions or kidney and hearing problems
Important warnings
- Avoid with intestinal obstruction or known allergy to aminoglycoside antibiotics.
- Inflamed or ulcerated bowel may increase absorption and toxicity.
- Use caution with kidney impairment or existing hearing problems.
- It does not treat amoebic infection outside the intestine.
Pregnancy
Absorption is usually low, but pregnancy data are limited; use only when clearly needed.
Breastfeeding
Absorption is usually low; limited evidence suggests low risk, but clinical guidance is appropriate.
Interactions
- Other medicines toxic to the kidneys or hearing may increase harm if paromomycin is absorbed.
- Medicines that slow gut movement may affect intestinal treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.