About bretylium tosylate
Class III antiarrhythmic agent
Used for
- Historically used for life-threatening ventricular arrhythmias, especially ventricular fibrillation.
Usual adult dose
For ventricular fibrillation: 5 mg/kg intravenously; may repeat or increase to 10 mg/kg if needed.
Common side effects
- Low blood pressure, especially when standing
- Nausea or vomiting
- Slow heart rate
- Abnormal heart rhythms
Important warnings
- Use requires continuous heart monitoring and emergency-care supervision.
- Can cause severe low blood pressure or worsen abnormal rhythms.
- Availability and approved uses vary by country.
Pregnancy
Human pregnancy data are limited; use only when the potential benefit justifies possible fetal risk.
Breastfeeding
It is unknown whether bretylium passes into breast milk; breastfeeding safety has not been established.
Interactions
- Medicines that lower blood pressure may increase hypotension.
- Other medicines affecting heart rhythm may increase arrhythmia risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.