About Nausetron 4mg/5ml Oral Solution
Serotonin 5-HT3 receptor antagonist
Used for
- Prevents nausea and vomiting caused by chemotherapy
- Prevents nausea and vomiting caused by radiotherapy
- Prevents nausea and vomiting after surgery
Usual adult dose
Chemotherapy: 8 mg before treatment, repeated eight hours later; then 8 mg twice daily for 1–2 days. Other uses have different schedules.
Usual dose in children
Chemotherapy, ages 4–11: 4 mg before treatment, repeated four and eight hours later; then 4 mg three times daily for 1–2 days.
Common side effects
- Headache
- Constipation
- Diarrhea
- Flushing
Important warnings
- Can cause abnormal heart rhythms, particularly with low potassium or magnesium
- Avoid in congenital long QT syndrome
- Severe liver impairment: maximum total daily dose is 8 mg
- May mask worsening bowel blockage
Pregnancy
Some studies suggest a small increased risk of oral clefts with first-trimester use. Use requires assessment of benefits and risks.
Breastfeeding
Limited evidence suggests low exposure through breast milk; no adverse effects have been reported in breastfed infants.
Interactions
- Apomorphine: combination contraindicated because of severe low blood pressure
- Medicines prolonging QT interval increase abnormal heart rhythm risk
- Serotonergic medicines, including some antidepressants, increase serotonin syndrome risk
- Carbamazepine, phenytoin, and rifampicin may reduce effectiveness
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.