About palbocicli b
Cyclin-dependent kinase 4/6 inhibitor
Used for
- Treats certain hormone receptor-positive, HER2-negative advanced breast cancers with hormone therapy.
Usual adult dose
125 mg by mouth once daily for 21 days, followed by 7 days off; dose may be reduced.
Common side effects
- Low white blood cell counts
- Infections
- Tiredness
- Nausea or mouth sores
Important warnings
- Can cause severe bone marrow suppression and serious infections.
- Blood counts require monitoring during treatment.
- Avoid grapefruit and strong CYP3A inhibitors or inducers.
- May harm an unborn baby; effective contraception is needed.
Pregnancy
May cause fetal harm; avoid during pregnancy.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least 3 weeks after the last dose.
Interactions
- Strong CYP3A inhibitors can raise palbociclib levels.
- Strong CYP3A inducers can lower palbociclib levels.
- Grapefruit may increase palbociclib levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.