About apremilast
Phosphodiesterase-4 inhibitor
Used for
- Plaque psoriasis
- Psoriatic arthritis
- Oral ulcers associated with Behçet disease
Usual adult dose
Usually 30 mg twice daily after a five-day dose increase; dose adjustment may be needed with severe kidney impairment.
Common side effects
- Diarrhea
- Nausea
- Headache
- Weight loss
Important warnings
- Weight loss can be significant; monitor weight.
- Mood changes, depression, or suicidal thoughts have been reported.
- Severe diarrhea, nausea, or vomiting may cause dehydration.
- Dose adjustment is needed with severe kidney impairment.
Pregnancy
Human pregnancy information is limited; use during pregnancy is generally avoided unless clearly needed.
Breastfeeding
It is not known whether apremilast passes into human milk; breastfeeding decisions should consider potential risks.
Interactions
- Strong enzyme-inducing medicines, such as rifampin, carbamazepine, phenytoin, and phenobarbital, may reduce effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.