About plecanatide
Guanylate cyclase-C agonist
Used for
- Chronic idiopathic constipation in adults
- Irritable bowel syndrome with constipation in adults
Usual adult dose
3 mg by mouth once daily, with or without food, for either approved use.
Common side effects
- Diarrhea
- Abdominal swelling
- Gas
- Dizziness
Important warnings
- Do not use in children under 6 years; severe dehydration may occur.
- Avoid in children aged 6 to under 18 years.
- Do not use with known or suspected intestinal blockage.
- Stop treatment and seek medical advice for severe diarrhea.
Pregnancy
Human pregnancy data are limited; absorption is minimal, so fetal exposure is expected to be low.
Breastfeeding
It is unknown whether plecanatide enters breast milk; minimal absorption makes exposure unlikely.
Interactions
- No clinically important drug interactions are established.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.