About brexpiprazole
Atypical antipsychotic
Used for
- Schizophrenia in adults
- Add-on treatment for major depressive disorder in adults
- Agitation associated with Alzheimer’s dementia in adults
Usual adult dose
Schizophrenia: start 1 mg once daily; usual 2–4 mg daily. Depression add-on: start 0.5–1 mg daily; usual 2 mg daily. Alzheimer’s agitation: titrate to 2 mg daily; maximum 3 mg.
Common side effects
- Weight gain
- Restlessness or akathisia
- Sleepiness or dizziness
- Headache
Important warnings
- Can increase blood sugar and cholesterol and cause weight gain.
- Increased risk of death in older adults with dementia-related psychosis.
- May cause compulsive gambling, shopping, eating, or sexual urges.
- Can impair alertness; use caution with driving and falls.
Pregnancy
May cause movement symptoms or withdrawal in newborns exposed late in pregnancy; discuss risks with a clinician.
Breastfeeding
Brexpiprazole may enter breast milk and could affect milk supply or the infant; evidence is limited.
Interactions
- Strong CYP2D6 or CYP3A4 inhibitors can raise levels; dose adjustment may be needed.
- Strong CYP3A4 inducers can lower levels; dose adjustment may be needed.
- Alcohol and sedating medicines can increase drowsiness and impaired coordination.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.