About zileuton
Leukotriene synthesis inhibitor
Used for
- Long-term asthma control and prevention
Usual adult dose
1,200 mg twice daily, within one hour after morning and evening meals.
Common side effects
- Headache
- Nausea
- Abdominal pain
- Elevated liver enzymes
Important warnings
- Not for sudden asthma attacks.
- Liver injury can occur; liver tests are required before and during treatment.
- Stop and seek medical care for signs of liver problems, such as jaundice or dark urine.
- Mood or behavior changes have been reported.
Pregnancy
Human pregnancy data are limited; use only when potential benefit justifies potential risk.
Breastfeeding
It is unknown whether zileuton passes into breast milk; effects on a nursing infant are unknown.
Interactions
- Theophylline levels can rise; dose adjustment and monitoring may be needed.
- Warfarin effects can increase; monitor clotting tests closely.
- Propranolol levels can rise, increasing effects such as slow heartbeat.
- Avoid interacting medicines that may increase liver injury risk; review treatment with a clinician.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.