About vortioxtine
Serotonin modulator antidepressant
Used for
- Major depressive disorder in adults
Usual adult dose
Usually 10 mg once daily; may increase to 20 mg or decrease to 5 mg daily.
Common side effects
- Nausea
- Constipation
- Vomiting
- Sexual difficulties
Important warnings
- Increased suicidal thoughts or behavior, especially early in treatment or after dose changes
- Risk of serotonin syndrome, particularly with other serotonin-acting medicines
- Stopping suddenly may cause withdrawal symptoms
- May increase bleeding risk, especially with blood thinners or anti-inflammatory pain medicines
Pregnancy
Use during pregnancy requires careful assessment; late-pregnancy exposure may cause newborn complications. Do not stop suddenly without medical guidance.
Breastfeeding
Breastfeeding safety is uncertain; vortioxetine may enter breast milk.
Interactions
- MAO inhibitors: serious serotonin syndrome risk
- Other serotonergic medicines, including tramadol or triptans: serotonin syndrome risk
- Strong CYP2D6 inhibitors, such as bupropion, may raise levels
- Rifampin and other enzyme inducers may lower levels
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.