About vortioxetine
Serotonin modulator antidepressant
Used for
- Treatment of major depressive disorder in adults
Usual adult dose
Usually 10 mg once daily; adjusted to 5–20 mg daily according to response and tolerability.
Common side effects
- Nausea
- Constipation
- Vomiting
- Dizziness
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Do not stop suddenly without medical guidance; withdrawal symptoms can occur.
- May cause serotonin syndrome, particularly with other serotonergic medicines.
- Increased bleeding risk, especially with anticoagulants or anti-inflammatory medicines.
Pregnancy
Use only when benefits outweigh risks; late-pregnancy exposure may cause newborn complications.
Breastfeeding
Information is limited; discuss potential infant effects and treatment benefits with a healthcare professional.
Interactions
- MAO inhibitors: serious serotonin syndrome risk; required washout periods apply.
- Other serotonergic medicines, including tramadol and triptans, may increase serotonin syndrome risk.
- Strong CYP2D6 inhibitors, such as bupropion or fluoxetine, can increase vortioxetine levels.
- Rifampin and other strong enzyme inducers can lower vortioxetine levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.