About vorinostat
Histone deacetylase inhibitor
Used for
- Treats cutaneous T-cell lymphoma in adults after other treatments have not worked.
Usual adult dose
400 mg by mouth once daily with food.
Common side effects
- Diarrhea, nausea, vomiting, and reduced appetite
- Tiredness and weakness
- Low blood cell counts
- Blood clots
Important warnings
- Can cause serious dehydration and electrolyte changes.
- May cause blood clots or abnormal heart rhythm.
- Can harm an unborn baby; effective contraception is recommended during treatment.
- Monitor blood counts, electrolytes, and kidney function.
Pregnancy
May cause fetal harm. Human pregnancy data are limited; avoid use during pregnancy.
Breastfeeding
Breastfeeding is not recommended during treatment or for one week after the final dose.
Interactions
- Valproic acid can increase low platelet counts and bleeding risk.
- Other medicines that prolong the QT interval may increase heart rhythm risks.
- Coumarin anticoagulants, such as warfarin, may require closer monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.