About vonoprazan
Potassium-competitive acid blocker
Used for
- Treatment of erosive esophagitis and heartburn
- Maintenance healing of erosive esophagitis
- Treatment of stomach or duodenal ulcers with antibiotics for H. pylori
- Prevention of ulcers caused by nonsteroidal anti-inflammatory drugs
Usual adult dose
Usually 20 mg once daily for up to 8 weeks for erosive esophagitis; 10 mg once daily for maintenance, up to 6 months. Other uses vary by regimen.
Common side effects
- Diarrhea
- Abdominal pain
- Nausea
- Headache
Important warnings
- Long-term use may increase risk of certain infections, fractures, and low magnesium or vitamin B12.
- Rarely, serious allergic reactions or kidney inflammation can occur.
- Some uses require combination with antibiotics; follow the prescribed regimen.
Pregnancy
Human pregnancy data are limited; use only when clearly needed after weighing potential benefits and risks.
Breastfeeding
It is unknown whether vonoprazan enters human milk; discuss potential risks and benefits with a clinician.
Interactions
- May reduce absorption of medicines needing stomach acid, such as some antifungals.
- Can increase levels of certain medicines, including some HIV drugs and methotrexate.
- Avoid with rilpivirine-containing products; interactions may reduce effectiveness or increase harm.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.