About vismodegib
Hedgehog pathway inhibitor
Used for
- Treats adults with basal cell carcinoma that has spread or returned after surgery, or cannot be treated with surgery or radiation.
Usual adult dose
150 mg by mouth once daily; continue until progression or unacceptable side effects.
Common side effects
- Muscle spasms
- Hair loss
- Taste changes
- Weight loss and tiredness
Important warnings
- Can cause severe birth defects or death of an unborn baby.
- Pregnancy prevention requirements apply during treatment and for 24 months afterward.
- Do not donate blood during treatment or for 24 months afterward.
- May cause muscle problems and elevated muscle enzyme levels.
Pregnancy
Do not use during pregnancy; it can cause embryo-fetal death or severe birth defects.
Breastfeeding
Do not breastfeed during treatment or for 24 months after the last dose.
Interactions
- Vismodegib can inhibit BCRP; it may increase exposure to BCRP substrates such as rosuvastatin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.