About vemurafeni b
BRAF kinase inhibitor
Used for
- Treats unresectable or metastatic melanoma with a BRAF V600 mutation.
- Treats Erdheim–Chester disease with a BRAF V600 mutation.
Usual adult dose
960 mg by mouth twice daily, as directed by a specialist.
Common side effects
- Joint pain, fatigue, rash, and hair loss
- Nausea, diarrhea, or sun sensitivity
- Skin cancers, including squamous-cell carcinoma
- Heart rhythm changes or liver problems
Important warnings
- Requires confirmation of a BRAF V600 mutation before treatment.
- Can cause serious skin reactions and new skin cancers.
- May prolong the QT interval; heart monitoring may be needed.
- Avoid excessive sunlight and use sun protection.
Pregnancy
May harm an unborn baby; effective contraception is recommended during treatment and for 2 weeks afterward.
Breastfeeding
Avoid breastfeeding during treatment and for 2 weeks after the last dose.
Interactions
- May interact with medicines that affect heart rhythm.
- Can reduce effectiveness of hormonal contraceptives.
- May alter levels of medicines metabolized by CYP enzymes.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.