About meropenem trihydrate + vaborbactam
Carbapenem antibiotic and beta-lactamase inhibitor
Used for
- Complicated urinary tract infections, including kidney infections, caused by susceptible bacteria.
Usual adult dose
4 g intravenously every 8 hours, infused over 3 hours; usual treatment is 7–14 days.
Common side effects
- Headache
- Diarrhea
- Infusion-site reactions
- Nausea
Important warnings
- For serious bacterial infections; use only when caused by susceptible bacteria.
- Allergic reactions may occur, especially with penicillin or cephalosporin allergy.
- Seizures and other nervous-system effects are possible, particularly with kidney impairment.
- Dose adjustment is needed for reduced kidney function.
Pregnancy
Human pregnancy data are limited; use when the potential benefit justifies possible fetal risk.
Breastfeeding
It is unknown whether the medicines enter human milk; consider potential infant effects and treatment benefits.
Interactions
- Probenecid can increase meropenem exposure.
- Valproic acid or divalproex levels may fall, increasing seizure risk.
- Meropenem may reduce mycophenolate exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.