About trofinetide
Rett syndrome treatment
Used for
- Treats Rett syndrome in adults and children aged 2 years and older.
Usual adult dose
By mouth twice daily, based on body weight: 6,000–12,000 mg per dose.
Usual dose in children
Age 2 years and older: twice daily, based on body weight. Under 12 kg: 5,000 mg; 12–20 kg: 6,000 mg; 20–35 kg: 8,000 mg; 35–50 kg: 10,000 mg; over 50 kg: 12,000 mg per dose.
Common side effects
- Diarrhea
- Vomiting
- Weight loss
- Fever
Important warnings
- Diarrhea can be severe and may require treatment or dose adjustment.
- Monitor weight; reduced appetite and weight loss may occur.
- Use caution with severe kidney problems; dose reduction may be needed.
- Stop treatment if a severe hypersensitivity reaction occurs.
Pregnancy
Human pregnancy information is insufficient to determine risks.
Breastfeeding
It is unknown whether trofinetide passes into breast milk; effects on infants are uncertain.
Interactions
- No clinically significant drug interactions are established.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.