About trisenox
Anticancer medicine; arsenic compound
Used for
- Treats acute promyelocytic leukemia (APL), often with other cancer medicines.
Usual adult dose
Usually 0.15 mg/kg intravenously once daily; treatment duration depends on the regimen and phase.
Usual dose in children
Specialist dosing is used for children with APL; regimen and dose are individualized.
Common side effects
- Nausea, vomiting, diarrhea, or abdominal pain
- Fatigue, fever, headache, or swelling
- Low blood-cell counts and infections
- Abnormal heart rhythm or liver-test results
Important warnings
- Can cause life-threatening heart rhythm problems; ECG and electrolyte monitoring are needed.
- May cause differentiation syndrome, with fever, breathing problems, swelling, or rapid weight gain.
- Can cause severe liver problems and low blood-cell counts.
- Treatment requires specialist supervision and regular blood tests.
Pregnancy
May harm an unborn baby. Pregnancy testing and effective contraception are advised during treatment and for 6 months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for 2 weeks after the final dose.
Interactions
- Medicines that prolong the QT interval can increase risk of dangerous heart rhythms.
- Medicines that affect electrolytes or heart rhythm require careful review.
- Strong CYP3A4 inhibitors or inducers may alter arsenic exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.