About trimipramine
Tricyclic antidepressant
Used for
- Major depressive disorder
- Sometimes used off-label for insomnia
Usual adult dose
Depression: usually 75–150 mg daily in divided doses; adjusted gradually. Some people require up to 200–300 mg daily under supervision.
Common side effects
- Sleepiness, dizziness, and impaired coordination
- Dry mouth, constipation, blurred vision, and difficulty urinating
- Weight gain and increased appetite
- Low blood pressure, rapid heartbeat, or heart rhythm changes
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause dangerous overdose effects, including seizures and heart rhythm problems.
- Avoid stopping suddenly; withdrawal symptoms may occur.
- Use caution with glaucoma, urinary retention, heart disease, seizures, or bipolar disorder.
Pregnancy
Use only when clearly needed; discuss risks and benefits with a healthcare professional. Exposure near delivery may affect the newborn.
Breastfeeding
May pass into breast milk and cause infant sleepiness or feeding problems; clinical guidance is recommended.
Interactions
- MAO inhibitors: potentially life-threatening reactions; avoid combination and observe required washout periods.
- Alcohol, opioids, and sedatives can worsen drowsiness and impaired coordination.
- Other medicines that affect serotonin may increase serotonin syndrome risk.
- Medicines affecting heart rhythm or trimipramine breakdown may increase cardiac or other adverse effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.