About treprostinil
Prostacyclin vasodilator
Used for
- Treats pulmonary arterial hypertension (PAH) to improve exercise ability and symptoms.
Usual adult dose
Continuous infusion, starting at 1.25 ng/kg/min; adjusted gradually according to response and tolerability.
Usual dose in children
Not routinely established; specialist dosing may be used for children with PAH.
Common side effects
- Headache
- Diarrhoea
- Nausea
- Jaw pain
Important warnings
- Must be given by continuous infusion; sudden interruption can worsen PAH.
- Infusion-site pain and reactions are common with subcutaneous administration.
- May cause low blood pressure or increase bleeding risk.
- Use specialist supervision; monitor for worsening PAH and infusion complications.
Pregnancy
Use only when the expected benefit outweighs potential risks; pregnancy data are limited.
Breastfeeding
It is not known whether treprostinil passes into breast milk; information is limited.
Interactions
- Anticoagulants and antiplatelet medicines may increase bleeding risk.
- Other blood-pressure-lowering medicines may increase low blood pressure.
- CYP2C8 inhibitors or inducers can alter treprostinil levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.