About treprostin il
Prostacyclin analogue vasodilator
Used for
- Pulmonary arterial hypertension to improve exercise ability and symptoms
Usual adult dose
Continuous intravenous or subcutaneous infusion, usually starting at 1.25 nanograms/kg/minute; gradually increased according to response and tolerability.
Common side effects
- Headache and flushing
- Nausea and diarrhea
- Jaw pain
- Pain or redness at subcutaneous infusion sites
Important warnings
- Abrupt interruption or large dose reductions can dangerously worsen pulmonary hypertension.
- May cause low blood pressure and fainting.
- Increases bleeding risk.
- Intravenous catheters can cause serious bloodstream infections.
Pregnancy
Human pregnancy data are limited. Pulmonary arterial hypertension itself carries serious risks during pregnancy.
Breastfeeding
Whether treprostinil enters human milk is unknown; effects on breastfed infants are uncertain.
Interactions
- Anticoagulants and antiplatelet medicines increase bleeding risk.
- Blood pressure medicines can increase low blood pressure risk.
- Gemfibrozil may increase treprostinil exposure.
- Rifampicin may reduce treprostinil exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.