About treosulfan
Alkylating chemotherapy medicine
Used for
- With fludarabine before stem-cell transplantation for certain blood cancers and disorders.
Usual adult dose
Usually 10–14 g/m² by intravenous infusion daily for three days, with fludarabine, before transplantation.
Usual dose in children
Usually 10–14 g/m² intravenously daily for three days, with fludarabine; dosing depends on age and body size.
Common side effects
- Low blood cell counts and increased infection or bleeding risk
- Nausea, vomiting, diarrhoea, or mouth sores
- Liver problems
- Skin rash or hair loss
Important warnings
- Specialist cancer treatment; blood counts and organ function require monitoring.
- Can cause severe infections, bleeding, or prolonged bone-marrow suppression.
- May harm an unborn baby; effective contraception is required during treatment.
- Avoid live vaccines during treatment; tell clinicians about all medicines and vaccines.
Pregnancy
May cause fetal harm. Avoid pregnancy during treatment; follow the treating specialist’s contraception guidance.
Breastfeeding
Breastfeeding is not recommended during treatment because of potential serious harm to the infant.
Interactions
- Other medicines that suppress bone marrow may increase blood-cell complications.
- Live vaccines may cause infection and should be avoided during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.