About trazodone
Serotonin antagonist and reuptake inhibitor
Used for
- Major depressive disorder
- Off-label use for insomnia
Usual adult dose
Depression: usually 150 mg daily in divided doses; gradually increased if needed. Insomnia dosing varies and is off-label.
Common side effects
- Drowsiness
- Dizziness
- Dry mouth
- Nausea
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause serotonin syndrome, abnormal heart rhythms, or prolonged erection.
- Avoid stopping suddenly; withdrawal symptoms may occur.
- May impair alertness; alcohol can worsen drowsiness.
Pregnancy
Use during pregnancy only when a clinician determines benefits outweigh potential risks; evidence is limited.
Breastfeeding
Trazodone enters breast milk in small amounts; infant effects are uncertain.
Interactions
- MAO inhibitors and other serotonergic medicines can cause serotonin syndrome.
- Alcohol and sedatives increase drowsiness.
- Medicines affecting heart rhythm may increase abnormal rhythm risk.
- Strong CYP3A4 inhibitors can raise trazodone levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.