About tofe rsen
Antisense oligonucleotide
Used for
- Treats adults with amyotrophic lateral sclerosis (ALS) caused by a confirmed SOD1 gene mutation.
Usual adult dose
Intrathecal injection: 100 mg every 14 days for three doses, then every 28 days.
Common side effects
- Pain, fatigue, joint or muscle pain
- Increased cerebrospinal fluid protein
- Raised cerebrospinal fluid white blood cell count
- Spinal cord inflammation or nerve-root pain
Important warnings
- Given into the spinal canal by trained healthcare professionals.
- May cause serious inflammation of the spinal cord or nerve roots.
- Monitoring may include neurological examinations and cerebrospinal fluid tests.
Pregnancy
Human pregnancy information is limited; potential risks are uncertain.
Breastfeeding
It is not known whether tofersen passes into breast milk; effects on infants are uncertain.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.