About tivozanib
Vascular endothelial growth factor receptor inhibitor
Used for
- Treats advanced renal cell carcinoma in adults, usually after previous treatment.
Usual adult dose
1.34 mg by mouth once daily for 21 days, then 7 days off; repeat cycles.
Common side effects
- High blood pressure
- Diarrhea
- Fatigue
- Hoarse voice
Important warnings
- Can cause severe high blood pressure, bleeding, blood clots, or heart problems.
- May impair wound healing; treatment is stopped before planned surgery.
- Can cause liver problems, protein in urine, or thyroid disorders.
- Avoid grapefruit and grapefruit juice.
Pregnancy
May harm an unborn baby. Effective contraception is needed during treatment and for at least one month afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one month after the last dose.
Interactions
- Strong CYP3A inducers can lower tivozanib levels and reduce effectiveness.
- Other medicines that raise blood pressure may worsen hypertension.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.