About tigecyclin e + vial
Glycylcycline antibiotic
Used for
- Complicated skin and skin-structure infections
- Complicated intra-abdominal infections
- Community-acquired bacterial pneumonia
Usual adult dose
100 mg intravenously once, then 50 mg every 12 hours; usually 5–14 days, depending on infection.
Usual dose in children
For ages 8–11: 1.2 mg/kg intravenously every 12 hours (maximum 50 mg per dose). Ages 12–17: 50 mg every 12 hours. Use is restricted to serious infections when alternatives are unsuitable.
Common side effects
- Nausea and vomiting
- Diarrhea
- Abdominal pain
- Liver-enzyme changes
Important warnings
- May increase all-cause mortality; reserve for situations where alternatives are unsuitable.
- Not approved for children under 8; can harm developing teeth and bones.
- Use caution with liver impairment; dose reduction may be needed in severe impairment.
- Seek prompt care for severe or persistent diarrhea, which may signal serious bowel infection.
Pregnancy
May harm fetal tooth and bone development, especially during the second and third trimesters; use only when clearly needed.
Breastfeeding
It is not known whether tigecycline enters human milk. Consider infant exposure and the importance of treatment when deciding whether to breastfeed.
Interactions
- Warfarin: may increase anticoagulant effects; monitor clotting tests.
- Oral hormonal contraceptives may be less effective; use additional contraception.
- May interact with calcineurin inhibitors such as tacrolimus or cyclosporine; monitor levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.