About tigecyclin e
Glycylcycline antibiotic
Used for
- Complicated skin and soft-tissue infections
- Complicated intra-abdominal infections
- Community-acquired bacterial pneumonia in adults
Usual adult dose
Usually 100 mg intravenously once, then 50 mg every 12 hours; typically 5–14 days.
Common side effects
- Nausea and vomiting
- Diarrhea
- Abdominal pain
- Raised liver enzymes
Important warnings
- Not suitable for bloodstream infections or diabetic foot infections.
- Can increase mortality risk compared with some alternatives; reserve for situations where alternatives are unsuitable.
- May cause pancreatitis, liver problems, or severe allergic reactions.
- Can harm developing teeth and bones; generally avoided during pregnancy and in children under 8.
Pregnancy
May harm fetal bone and tooth development; use is generally avoided unless clearly necessary.
Breastfeeding
It is unknown how much passes into breast milk; consider infant effects and treatment necessity.
Interactions
- Warfarin: may increase anticoagulant effects; monitor clotting tests.
- May reduce hormonal contraceptive effectiveness; additional contraception may be needed.
- May interact with calcineurin inhibitors such as tacrolimus or cyclosporine.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.